Hospira Fentanyl Citrate 250 Mcg/5 ML Injection Vial USP

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Hospira Fentanyl Citrate 250 Mcg/5 ML Injection Vial USP

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Description

Hospira Fentanyl Citrate 250 Mcg/5 ML Injection Vial USP

Hospira Fentanyl Citrate 250 mcg/5 mL Injection Vial, USP is a potent o p i o i d ag o nis t . Each milliliter of solution contains fentanyl citrate
equivalent to 50 mcg of fentanyl base, adjusted to pH 4.0 to 7.5 with sodium hydroxide.
Fentanyl citrate is chemically identified as N-(1-phenethyl-4-piperidyl) propionanilide citrate (1:1) with a molecular weight of
528.60. The empirical formula is C22H28N2O • C6H8O7. The structural formula of fentanyl citrate is fentanyl Citrate Injection, USP is a sterile, non-pyrogenic, preservative free aqueous solution for intravenous or
intramuscular injection.

CLINICAL PHARMACOLOGY.

Fentanyl citrate is a potent opioid agonist. A dose of 100 mcg (0.1 mg) (2.0 mL) is approximately equivalent in
analgesic activity to 10 mg of morphine or 75 mg of meperidine. The principal actions of therapeutic value are
analgesia and sedation. Alterations in respiratory rate and alveolar ventilation, associated with opioid analgesics,
may last longer than the analgesic effect. As the dose of fentanyl is increased, the decrease in pulmonary exchange
becomes greater. Large doses may produce apnea. Fentanyl appears to have less emetic activity than either
morphine or meperidine. Histamine assays and skin wheal testing in man indicate that clinically significant
histamine release rarely occurs with fentanyl. Recent assays in man show no clinically significant histamine release
in dosages up to 50 mcg/kg (0.05 mg/kg) (1 mL/kg). Fentanyl preserves cardiac stability, and blunts stress-related
hormonal changes at higher doses.

Additional information

Quantity

3 Ampoules, 5 Ampoules, 10 Ampoules, 15 Ampoules, 20 Ampoules

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